Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington’s disease.
Authors: McFarland, Karen N Das, Sudeshna Sun, Ting Ting Leyfer, Dmitri Xia, Eva Sangrey, Gavin R Kuhn, Alexandre Luthi-Carter, Ruth Clark, Timothy W Sadri-Vakili, Ghazaleh Cha, Jang-Ho J In Huntington's disease (HD; MIM ID #143100), a fatal neurodegenerative disorder, transcriptional dysregulation is a key pathogenic feature. Histone modifications are altered in multiple cellular and animal … Read more